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AK-B48 (APINACA, N-(1-adamantyl)-1-pentyl-1H-indazole-3-carboxamide) is a substance which behaves as a reasonably powerful agonist for the cannabinoid receptors, with a Ki of 304.5nM and a EC50 of 585nM at CB1.
It had never before been documented within medical or even patent literature, and was initially discovered by research labs in The Japanese Islands in March 2012 as being an element in artificial marijuanasmoking blends, together with a relevant substance APICA.
Structurally it closely looks like cannabinoid ingredients from patent WO 2003/035005, but using a simple pentyl chain on the indazole 1-position, AKB48 falls inside of the claims of this patent regardless not disclosed as an example.
AKB48 came to be prohibited in The Japanese Islands in 2012, and ended up being prohibited as a temporary class drug in New Zealand from 13 July 2012. It’s been prohibited in Latvia ever since fourteen November 2013.
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